| CODE | CPH5412 | ||||||||
| TITLE | Research and Statistical Methods in Pharmacotoxicology | ||||||||
| UM LEVEL | 05 - Postgraduate Modular Diploma or Degree Course | ||||||||
| MQF LEVEL | 7 | ||||||||
| ECTS CREDITS | 5 | ||||||||
| DEPARTMENT | Clinical Pharmacology and Therapeutics | ||||||||
| DESCRIPTION | This study-unit will provide a detailed overview of principles of research methodologies and statistics used in basic, molecular and clinical pharmacotoxicology.The study unit will introduce statistical and research concepts and terminology in pharmacotoxicology. Examples will be used to contextualize the discussions and the examples used throughout the lectures, for example in the correct use of the interpretation of data and statistical analysis in the pharmacotoxicology field. Research methodologies used in the basic, molecular and clinical pharmacotoxicology settings will be discussed with the support of practical hands on experiments and case studies. Ethics issues related to research methodology will also be discussed. Study-Unit Aims: - Research methodologies and the interpretation of results obtained from such reseach, requires a good foundation in statistics which is a key and important tool in in the basic, molecular and clinical pharmacotoxicology settings. - This study-unit aims to lay the necessary foundations in research methodology and statistical analysis in order to enable MSc Pharmacotoxicology students to understand the correct role of use of these methodologies in case studies and when undertaking research projects. - Students will receive a broad spectrum of applied pharmacotoxicology research methodologies and statistical methods, as related to different scenarios in toxicology, including ethical issues. Learning Outcomes: 1. Knowledge & Understanding: By the end of the study-unit the student will be able to: -Provide a detailed overview of research methodologies and statistical principles underlying pharmacotoxicology - Identify and distinguish the key underpinnings and practical foundations of different research methodologies and identify issues of reliability, trustworthiness and validity in data obtained from pharmacotoxicology research; - Describe the different uses of research methodologies and statistical methods in basic, molecular and clinical pharmacotoxicology, including strengths and limitations of different methods. - Explain the appropriate use of statistics in analyzing pharmacotoxicological data - Address ethical issues related to the selection of appropriate research methodologies and statistical analysis used in data obtained from pharmacotoxicological research 2. Skills: By the end of the study-unit the student will be able to: - Apply the knowledge acquired in this study unit in their dissertation - Identify research questions related to the study of pharmacotoxicology and identify gaps in the literature; - Discuss the appropriate role of statistics in making recommendations about analysis of results obtained from pharmacotoxicology experiments and research. - Source and comprehend various statistical techniques in order to conduct research in the field of pharmacotoxciology. Main Text/s and any supplementary readings: Main Texts: - Klaassen C, Watkins J (2015). Casarett & Doull's Essentials of Toxicology, McGraw Hill ISBN 3rd edition - Stine KE, Brown TM (2015). Principles of Toxicology. CRS Press (main library RA1211 .S75 2015) - Abby Calvin (2016). Textbook of Pharmacology and Toxicology. Syraword Publishing House. - Mitchell PJ (2022) Experimental Design and Statistical Analysis for Pharmacology and the Biomedical Sciences. Wiley-Blackwell. - Rowe P. (2015) Essential Statistics for the Pharmaceutical Sciences. Wiley-Blackwell; 2nd edition. Supplementary Readings: Klaassen C D.(2019). Casarett and Doull's toxicology: the basic science of poisons. 9th edition New York McGraw-Hill Education. - Sahota PS, Spaet PH, Bentley P, Wojcinski Z. (2019)The Illustrated Dictionary of Toxicologic Pathology and Safety Science. CRC Press - Raj GM and Raveendran IR (2019). Introduction to Basics of Pharmacology and Toxicology: Volume 1: General and Molecular Pharmacology: Principles of Drug Action. Springer. - Lew M, Good statistical practice in pharmacology Problem 1. Br J Pharmacol. 2007 Oct; 1Oct;152(3):295-83. - Lew M, Good statistical practice in pharmacology Problem 2. Br J Pharmacol. 2007 Oct; 152(3): 299鈥�303. Journals: - Toxicology - Pharmacology & toxicology - Toxicology methods - Reproductive toxicology - Clinical toxicology - Journal of toxicology - Human & experimental toxicology - International journal of toxicology - Toxicology mechanisms and methods - Toxicology and applied pharmacology - Chemical research in toxicology. |
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| STUDY-UNIT TYPE | Lecture and Independent Study | ||||||||
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The University makes every effort to ensure that the published Courses Plans, Programmes of Study and Study-Unit information are complete and up-to-date at the time of publication. The University reserves the right to make changes in case errors are detected after publication.
The availability of optional units may be subject to timetabling constraints. Units not attracting a sufficient number of registrations may be withdrawn without notice. It should be noted that all the information in the description above applies to study-units available during the academic year 2025/6. It may be subject to change in subsequent years. |
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