| CODE | MLS4007 | ||||||||
| TITLE | Applied Cellular Pathology | ||||||||
| UM LEVEL | 04 - Years 4, 5 in Modular UG or PG Cert Course | ||||||||
| MQF LEVEL | 6 | ||||||||
| ECTS CREDITS | 2 | ||||||||
| DEPARTMENT | Applied Biomedical Science | ||||||||
| DESCRIPTION | This study-unit deals with detailed knowledge on some specialised topics within the areas of Histopathology and Cytopathology, mainly autopsies, fluorescent in situ hybridisation, immunohistochemistry, cancer screening, quality control, borderline smears, national screening programmes and cytological diagnosis of specific problem areas. Students are expected to read and research further the topics presented in lectures and to present an assignment on his/her choice within the specialised area. Aims: The aim of this study-unit is for students to study in depth selected specialised techniques, within the areas of Histopathology and Cytopathology, and to discuss their application in clinical practice. Content: 鈥 The Role of the Autopsy 鈥 Safety Issues in the Histopathology Labs and Mortuary 鈥 Quality Assurance in Histopathology 鈥 Quality Assurance in Immunohistochemistry 鈥 Skin Immunoflourescence 鈥 The FISH Technique 鈥 The significance of the borderline smear 鈥 Diagnosis of mesothelioma 鈥 The role of HPV DNA testing 鈥 National Screening Programmes. Learning Outcomes: By the end of the study鈥恥nit the student should be able to: 鈥 Explain the basic autopsy procedure and outline the specialized techniques; 鈥 Discuss the role of the autopsy, differentiating between hospital and forensic autopsies; 鈥 Describe the practical application of immunohistochemical techniques in histopathology and cytology; 鈥 Outline the techniques and rationale of HPV DNA testing; 鈥 Assess the use and objectives of HPV DNA testing; 鈥 Discuss the use of the autopsy for audit purposes; 鈥 Appraise the health and safety issues in the mortuary; 鈥 Critically appraise the laboratory techniques employed in cellular pathology including direct immunofluorescene and FISH techniques; 鈥 Understand the basis of national screening programmes; 鈥 Discuss the features of borderline smears and the significance to patient management; 鈥 Discuss the problems in reaching a diagnosis of mesothelioma in cytology. Reading list: 鈥 Cross S. Underwood鈥檚 Pathology: a Clinical Approach (6th Edition), 2013. Churchill Livingstone (ISBN-13:9780702046728) 鈥 Reid R, Roberts F & Macuff E. Pathology Illustrated (7th Edition), 2011, Churchill Livingstone (ISBN: 9780702033766) 鈥 Laboratory Manuals, Protocols and Guidelines 鈥 Koss LG. Diagnostic Cytology and its Histological Bases, Volumes 1&2 (5th edition). Lippincott Williams & Wilkins. ISBN 0-7817-1928-3 鈥 Keebler C. The Manual of Cytotechnology (7th Edition), American Society of Clinical Pathologists (ASCP Press). ISBN 0-89189-352-0 鈥 Coleman D.V. and Chapman P.A. Clinical Cytotechnology. Butterworths. ISBN 0-407-00176-X 鈥 Cook, D. and Warren, P. (2015). Cellular pathology; an introduction to techniques and application.. 3rd ed. Scion Publishing Ltd. ISBN-13: 978-1907904356Cibas ES. & Ducatman B.S. Cytology (4th Edition) . Elsevier 鈥 Saunders ISBN 978-1-4557-4462-6 鈥 Nayar R. & Wilbur DC. The Bethesda System for Reporting Cervical Cytology (3rd Edition). Springer. ISBN 978-3-319-11073-8 鈥 Ali SZ & Cibas ES. The Bethesda System for Reporting Thyroid Cytopathology. Springer. ISBN 978-0-387-87665-8 鈥 Mac DeMay R. The Art & Science of Cytopathology, Volumes 1-4. American Society of Clinical Pathologists (ASCP Press). ISBN 9780891896449 鈥 Stevens A & Lowe J. Stevens & Lowe鈥檚 Human Histology (4th Edition). Elisevier 鈥 Saunders. ISBN 9780723435020 鈥 Stevens A & Lowe J. Stevens & Lowe鈥檚 Pathology. (2nd Edition). Mosby. ISBN 978-0397447640 Reference Texts 鈥 Herrington CS (Ed.). Muir's Textbook of Pathology (15th Edition), 2014. CRC Press (ISBN 9781444184976) 鈥 Kumar V, Abbas AK & Aster JC. Aster. Robbins and Cotran, Pathologic Basis of Disease (9th Edition), 2015. Elsevier Health Sciences (ISBN-13:9781455726134; ISBN-10:1455726133) 鈥 Kumar V, Abbas AK & Aster JC.. Aster. Robbins Basic Pathology (9th Edition), 2013. Elsevier Health Sciences (ISBN-13: 9781437717815; ISBN-10:1437717810) 鈥 Burton JL & Rutty G. The Hospital Autopsy: A Manual of Fundamental Autopsy Practice (3rd Edition), 2010. CRC Press (ISBN 9780340965146) 鈥 Kocjan G, Gray W, Levine T, Kardum-Skelin I & Vielh I. Diagnostic Cytopathology Essentials, 2013. Churchill Livingstone (ISBN: 9780702044502) 鈥 Suvarna, S., Layton, C. and Bancroft, J. (2018). Bancroft's theory and practice of histological techniques. 8th ed. Churchill Livingstone. ISBN-13: 978-0702068645. |
||||||||
| ADDITIONAL NOTES | Pre-Requisites Pathology PAT2121 and MLS3004 |
||||||||
| STUDY-UNIT TYPE | Lecture | ||||||||
| METHOD OF ASSESSMENT |
|
||||||||
| LECTURER/S | Charlene Busuttil Simona Buttigieg David Grima Mario Taliana |
||||||||
|
The University makes every effort to ensure that the published Courses Plans, Programmes of Study and Study-Unit information are complete and up-to-date at the time of publication. The University reserves the right to make changes in case errors are detected after publication.
The availability of optional units may be subject to timetabling constraints. Units not attracting a sufficient number of registrations may be withdrawn without notice. It should be noted that all the information in the description above applies to study-units available during the academic year 2025/6. It may be subject to change in subsequent years. |
|||||||||