| CODE | PHR1104 | ||||||||
| TITLE | Pharmaceutical Chemistry 2 | ||||||||
| UM LEVEL | 01 - Year 1 in Modular Undergraduate Course | ||||||||
| MQF LEVEL | 5 | ||||||||
| ECTS CREDITS | 6 | ||||||||
| DEPARTMENT | Pharmacy | ||||||||
| DESCRIPTION | Pharmaceutical Organic Chemistry - Types of chemical bonding. The relationship of chemical bonds to the structure and shape of molecules. Physical bonding, inter molecular and intra-molecular forces, donor-acceptor concepts, complex formation; - Stereochemistry of organic molecules; - Introduction, including bond lengths and angles, constitution, configuration and confirmation; - Optical isomerism including chirality; - Geometric isomerism; - Stereochemistry of reactions and conformations; - The relevance of molecular geometry to biological activity; - Projection formulae: Fischer, Newmann, sawhorse; - Properties of organic compounds; - An introduction to the more important mechanisms of organic reactions and the influence of electronic effects on their reactions (induction and mesomerism); - The chemistry of functional groups and the aliphatic and aromatic organic compounds. The chemistry of: - Polynuclear hydrocarbons such as naphthalene, anthracene; - The 5- and 6-membered heterocyclic aromatic compounds e.g. furan, thiophen, pyrrole, pyridine ciontaining one hetero atom; - The diazines and the triazines containing more than one hetero atom; - The fused ring systems e.g. indoles, purines; - Carbohydrates: mono-, di- and polysaccharides; - Amino acids, proteins, peptides; nucleotides and nucleic acids; - Fats and oils. Study-unit Aims: - To introduce students to the different types of chemical and physical bonding, and their relation to structure, shape and to the reactivity of molecules; - To introduce the basis of pharmaceutical and medicinal chemistry by introducing the more important mechanisms of organic reactions and the chemistry of functional groups and influence of different moieties on molecular stability and detection; - To outline the 3-dimensional nature of organic molecules and the nomenclature of stereochemistry in preparation for its application to drug design and its importance in biological activity; - To understand the basic principles underpinning the chemistry of aliphatic and aromatic compounds; - To highlight the chemistry of aromatic & heterocyclic compounds, carbohydrates, proteins, peptides, nucleotides and nucleic acids of special importance in pharmaceutical chemistry. Learning Outcomes: 1. Knowledge & Understanding: By the end of the study-unit the student will be able to: - Understand how different moieties affect the 3-dimensional structure of molecules; - Understand how different moieties affect molecules such as triglycerides, proteins and carbohydrates; - Understand the basic principles underpinning the chemistry of carbohydrates, proteins lipids and nucleic acid chemistry. 2. Skills: By the end of the study-unit the student will be able to: - Correlate the 3-dimensional structure of molecules with biological activity; - Correlate the 3-dimensionality of proteins and nucleic acids with the roles they play in interactions with small molecules. Main Text/s and any supplementary readings: Main Text/s: Hart H, Hart DJ, Crain LE. Organic Chemistry - A Short Course. USA: Hougthon Mifflin Co., Boston. 1995. ISBN 0-395-70838-9. Sykes P. A Guide Book to Mechanism in Organic Chemistry. UK: Wiley John & Sons, Inc. 1986. ISBN 0-470-20663-2. Supplementary Readings: Lemke TL. Review of Organic Functional Groups: Introduction to Medicinal Organic Chemistry. USA: Lea & Febiger 1991. ISBN 0-8121-1428-0. |
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| RULES/CONDITIONS | Before TAKING THIS UNIT YOU MUST TAKE PHR1103 | ||||||||
| STUDY-UNIT TYPE | Lecture and Tutorial | ||||||||
| METHOD OF ASSESSMENT |
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| LECTURER/S | Janis Vella |
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The University makes every effort to ensure that the published Courses Plans, Programmes of Study and Study-Unit information are complete and up-to-date at the time of publication. The University reserves the right to make changes in case errors are detected after publication.
The availability of optional units may be subject to timetabling constraints. Units not attracting a sufficient number of registrations may be withdrawn without notice. It should be noted that all the information in the description above applies to study-units available during the academic year 2025/6. It may be subject to change in subsequent years. |
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