| CODE | PHR3209 | ||||||||||||
| TITLE | Pharmaceutical Analysis 2 | ||||||||||||
| UM LEVEL | 03 - Years 2, 3, 4 in Modular Undergraduate Course | ||||||||||||
| MQF LEVEL | 6 | ||||||||||||
| ECTS CREDITS | 4 | ||||||||||||
| DEPARTMENT | Pharmacy | ||||||||||||
| DESCRIPTION | - An overview about instruments and consumables which are frequently used in the laboratory for pharmaceutical analysis is given. - Sample preparation techniques with particular focus on the handling of biological fluids are discussed. - Different types of biological fluids which are presented for analysis are discussed. - Special focus will be given to bioanalysis Bulk and instrumental separation techniques are discussed. Students are exposed to the practical application of instrumental methods of separation in Pharmaceutical Analysis. - Principles and fundamentals of toxicology and application of bioanalysis in relation to these principles are discussed. - Students are exposed to the practical application of instrumental methods of separation in Pharmaceutical Analysis. Study-Unit Aims: Completion of this study-unit will aim to: - Provide the student with an overall idea of the most popular separation techniques employed when conducting pharmaceutical analysis; - Highlight characteristics of different pharmaceutical analysis techniques whilst appreciating the influence of the chemical characteristics of the drug or analyte of interest when it comes to separating it from other components and analysing it; - Introduce procedures for extraction of drugs of interest from complex matrices such as biological fluids; - Appreciate the importance of appropriate sample preparation to be able to apply knowledge gained to practical scenarios following analysis; - Appreciate fundamental toxicological concepts; - Observe practical sessions and familiarise with procedures involved in analysis of drugs including troubleshooting and interpretation of results. Learning Outcomes: 1. Knowledge & Understanding By the end of the study-unit the student will be able to: - Understand and apply basic principles on which separation science is based as related to separating chemicals or drugs of interest from biological matrices; - Describe methods of sample preparation and extraction; - Compare characteristics of different analytical techniques used in bioanalysis. 2. Skills By the end of the study-unit the student will be able to: - Choose the most fitting technique for sample preparation- to select and be able to apply the most appropriate method of extraction to be used for separating drugs or other molecules of interest prior to further analysis; - Choose appropriate and relevant analytical method for the separation of compounds in relation to drug analysis; - Plan procedures and processes required in drug analysis; - Link appropriate sample preparation with a method or technique of analysis to be later applied in clinical settings or used in pharmacokinetic studies; - Appreciate principles and fundamentals of toxicology. Main Text/s and any supplementary readings: Main Texts: - Levine BS, Kerrigan S. Principles of Forensic Toxicology. 5th edn. USA: Springer, 2020 - Li W, Jian W, Fu Y. Sample Preparation in LC-MS Bioanalysis. USA: Wiley, 2019 - Stine KE, Brown TM. Principles of toxicology. 3rd Edn. Boca Raton: CRC Press, 2015 - Watson DG. Pharmaceutical Analysis: A Textbook for Pharmacy Students and Pharmaceutical Chemists, 5th Edn., Edinburgh: Elsevier Health Sciences UK, 2021. Supplementary Readings: - Moffat AC. Clarke's analysis of drugs and poisons Volume 1, 4th edn., London: Pharmaceutical Press, 2011 - Skoog DA, West DM, Holler FJ. Fundamentals of analytical chemistry 9th Edn., Philadelphia: Saunders College Publishing, 2013. |
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| RULES/CONDITIONS | Before TAKING THIS UNIT YOU MUST TAKE PHR2203 | ||||||||||||
| STUDY-UNIT TYPE | Lecture and Practical | ||||||||||||
| METHOD OF ASSESSMENT |
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| LECTURER/S | Janis Vella |
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The University makes every effort to ensure that the published Courses Plans, Programmes of Study and Study-Unit information are complete and up-to-date at the time of publication. The University reserves the right to make changes in case errors are detected after publication.
The availability of optional units may be subject to timetabling constraints. Units not attracting a sufficient number of registrations may be withdrawn without notice. It should be noted that all the information in the description above applies to study-units available during the academic year 2025/6. It may be subject to change in subsequent years. |
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