/library/oar/handle/123456789/42028 2025-11-05T17:40:47Z 2025-11-05T17:40:47Z Grech, Alfred Balzan, Michael /library/oar/handle/123456789/40259 2019-09-27T08:05:56Z 2018-01-01T00:00:00Z

Title: How and why we age : clinical implications Authors: Grech, Alfred; Balzan, Michael Abstract: If ageing is perceived as a disease, then there is the potential that we can cure it! But curing ageing entails understanding it. So far, understanding ageing has remained a challenge. However, observations and research, on model organisms and humans alike, are evolving fast. In this review, we will start with a discussion of both the damage and the programmed theories of ageing. Ultimately, we will focus on calorie restriction and telomere shortening and how these relate to lifespan extension.

2018-01-01T00:00:00Z /library/oar/handle/123456789/40257 2019-05-22T05:34:39Z 2018-01-01T00:00:00Z

Title: Nip and tuck... embrace the future Abstract: I wish to start 2018 by discussing gene editing which, following last year’s remarkable advances, is rumoured to continue to make a star appearance on stage. Gene editing basically rewrites DNA, disabling target genes, correcting harmful mutations and changing the activity of specific genes. This technology has already been used successfully in the agricultural industry, in that gene editing is faster and more precise than conventional genetic modification, with the added advantage of avoiding the addition of genes from other organisms [this has fuelled the backlash against GM crops]. Seedless tomatoes and gluten-free wheat are some of the results of gene editing.

2018-01-01T00:00:00Z Cilia Vincenti, Albert /library/oar/handle/123456789/40258 2019-05-22T05:35:46Z 2018-01-01T00:00:00Z

Title: Is lymphoma curable? Authors: Cilia Vincenti, Albert Abstract: This is early 1980s, a few years after I took up a consultant surgical pathologist post at the Royal Hampshire County Hospital in Winchester. I get a call from Dr Anthony Galea- Debono who is now a physician and neurologist in private practice in Malta. In the late 1970s, Tony and I used to meet often over lunch because we worked not far from each other in London, him at Queen’s Square and I at The Middlesex in Mortimer Street. The call from Galea-Debono is about a young woman in her early thirties who has been referred to him for management of a diagnosis of tuberculosis following an excision biopsy of an enlarged neck lymph node, and wishes the histology reviewed before he starts anti-tuberculous therapy. The lymph node histology, in fact, shows what I thought was a high grade large cell lymphoma with necrosis, the latter feature having been misinterpreted as tuberculous necrosis. The patient also complained of retrosternal pain on ingesting alcohol. I confirm the lymphoma diagnosis with Professor Dennis Wright, at the time a world figure in lymphoid pathology, and conveniently located in Southampton, just down the road from Winchester.

2018-01-01T00:00:00Z Vassallo, Pierre /library/oar/handle/123456789/40256 2019-05-22T05:41:03Z 2018-01-01T00:00:00Z

Title: Imaging breast implant rupture : part 1 Authors: Vassallo, Pierre Abstract: Breast augmentation is the most common form of cosmetic surgery performed today. Most procedures involve the insertion of silicone gel-filled prostheses, which are selected for size and contour based on the woman’s body habitus and preference. The first gel-filled breast implants were developed in the early 1960’s, however these suffered from high material failure rates and were initially thought to be linked to connective tissue disorders. Major redesigns and material improvements have lead to the development of 4th and 5th generation implants that have semi-solid silicone filler-gel and a strong silicone capsule. These new implants have the advantage of retaining their original shape and have a lower risk for rupture.

2018-01-01T00:00:00Z