/library/oar/handle/123456789/42849 2025-11-10T01:31:13Z 2025-11-10T01:31:13Z Mifsud, Melise Salem, Mohamed A. /library/oar/handle/123456789/42864 2019-05-07T01:28:00Z 2019-04-01T00:00:00Z

Title: Hyperglycaemic hyperosmolar non ketotic coma Authors: Mifsud, Melise; Salem, Mohamed A. Abstract: A case report discussing the management of a patient with hyperosmolar hyperglycaemic state. This is intended to raise awareness about this complication of Type 2 diabetes and the factors that lead to it. HSS is mostly caused by severe dehydration and sepsis. Elderly patients often do not drink enough and infection is commonly seen in patients living in a hospitalised environment.

2019-04-01T00:00:00Z Fenech, Valentina Pavia, Norma Frendo, Michaela /library/oar/handle/123456789/42863 2019-10-14T08:57:13Z 2019-04-01T00:00:00Z

Title: An unusual cause for fever : a case report on microscopic polyangiitis Authors: Fenech, Valentina; Pavia, Norma; Frendo, Michaela Abstract: Microscopic polyangiitis (MPA) is a small-vessel vasculitis which results in pauci-immune necrotizing inflammation of blood vessel walls. In this report, we describe a case of MPA in a 65-year old female who presented with a 1 month history of lower back pain followed by reduced appetite, weight loss and fever. An immunology screen detected perinuclear anti-neutrophil cytoplasmic antibodies (p-ANCA) with myeloperoxidase (MPO) specificity in the serum. A renal biopsy was obtained because of mild proteinuria on urinalysis and revealed a small vessel vasculitis consistent with MPA. She is being treated with glucocorticoids and cyclophosphamide which resulted in a positive clinical response, with resolution of fever and improvement in her inflammatory markers. Currently she is stable and since starting treatment, she has not had any relapses or flare ups.

2019-04-01T00:00:00Z Fenech, Matthew T. Mifsud, Adrian Carbonaro, Francis /library/oar/handle/123456789/42862 2022-03-10T06:51:01Z 2019-04-01T00:00:00Z

Title: Preliminary trabeculectomy results using the Moorfields safer surgery technique in Malta Authors: Fenech, Matthew T.; Mifsud, Adrian; Carbonaro, Francis Abstract: Purpose: To review the results of the Moorfields Safer Surgery System (MSSS) for trabeculectomy, recently introduced in Malta. Methods: Patient files were reviewed from data collected over an 18 month period, from the Maltese national teaching hospital, Mater Dei Hospital. Files of all patients undergoing primary trabeculectomy with a minimum of 12 months follow up data available were reviewed. Primary outcome measure of success was defined as a 30% drop in final post-operative intraocular pressure (IOP) at 1 year. Secondary outcome measure of success was final post-op IOP of less than 21mmHg. Unqualified success was defined as satisfactory IOP without the need of anti-glaucoma medication, while qualified success was defined as satisfactory IOP in those patients requiring anti-glaucoma medication. Results: 43 eyes (mean age = 66.2 yrs ± 11.7) were analysed. The mean pre-operative IOP was 27.0mmHg ± 4.6. Mean post-op IOP at one year was 15.3mmHg ±2.7. Unqualified success for the primary outcome measure was achieved in 64.1% of patients while the qualified success was achieved in 82.1%. Unqualified success for the secondary outcome measure was achieved in 72.7% and a qualified success, of 94.8% was obtained. There was 6.8% failure rate. Conclusions: The results from this first review using the Moorfields safe surgery system for Trabeculectomy surgery in the Maltese islands compares well to the current literature.

2019-04-01T00:00:00Z /library/oar/handle/123456789/42857 2020-05-15T07:09:10Z 2019-05-01T00:00:00Z

Title: Exercise : an anti-cancer agent Abstract: Elevated levels of insulin and insulin-like growth factor (IGF) have been implicated as risk factors for cancer, and indeed, fasting and fasting-mimicking diet appear to promote protection of normal cells and induce cancer cell death. It is for this reason that it is believed that these two hormones are also the leading candidates to explain the correlation between obese and diabetic individuals and cancer risk. Moreover, such individuals are less likely to have a good prognosis under such circumstances than leaner equivalents.

2019-05-01T00:00:00Z