/library/oar/handle/123456789/906 Sat, 27 Dec 2025 05:07:46 GMT 2025-12-27T05:07:46Z /library/oar/handle/123456789/141614 Title: Molecular logic gates as fluorescent markers and DNA binding agents Abstract: N/A Description: Ph.D.(Melit.) Sun, 01 Jan 2023 00:00:00 GMT /library/oar/handle/123456789/141614 2023-01-01T00:00:00Z /library/oar/handle/123456789/140715 Title: N-unsubstituted dihydropyridines and pyridones via multicomponent synthesis under a bio-derived heterogeneous catalyst Authors: Bosica, Giovanna; Abdilla, Roderick Abstract: In our exploration of metal-free and cost-effective heterogeneous catalysts for MCRs, we identified a novel system: piperazine immobilized within an agar matrix, functioning as a recyclable and reusable catalyst. This system efficiently facilitates the synthesis of dihydropyridines (DHPs) via one-pot condensation of dimedone, aldehydes, ammonium acetate, and various active methylene compounds—specifically malononitrile, acetophenone, or Meldrum's acid. A broad range of products was obtained, underscoring the versatility of the methodology. Notably, our prior investigations demonstrated this catalyst's efficacy in synthesizing N-aryl-substituted DHPs, affirming its general applicability. Additionally, fluorescence and UV absorption studies, along with in-depth characterization using 2D NMR spectroscopy, were conducted to confirm the structure and peak assignments of the synthesized products. Wed, 01 Jan 2025 00:00:00 GMT /library/oar/handle/123456789/140715 2025-01-01T00:00:00Z /library/oar/handle/123456789/140251 Title: Naphthalimide–organometallic hybrids as multi-targeted anticancer and luminescent cellular imaging agents Authors: Magri, David C.; Johnson, Alex D. Abstract: 1,8-Naphthalimides with an organometallic moiety with anticancer and luminescence or photoactive properties are reviewed. Primarily highlighted are 1,8-naphthalimide complexes with iron, platinum, and ruthenium, while honourable mentions are given to iridium, rhenium and rhodium complexes. The cytotoxicity, mechanism of action and cell selectivity of the compounds are discussed alongside their photophysical properties for monitoring interactions with biomolecules, most notably DNA, by absorption, fluorescence and dichroism spectroscopy. The luminescence properties provide additional insight regarding the cellular uptake and location of the intelligent agents within both cancer and healthy cells. The versatility of this emerging hybrid class of molecules earmarks them as multi-functional therapeutic and cellular imaging agents. The review concludes with suggestions for designing more effective multi-targeting cytotoxic agents with improved biocompatibility and imaging in hopes of enhancing their clinical potential. Wed, 01 Jan 2025 00:00:00 GMT /library/oar/handle/123456789/140251 2025-01-01T00:00:00Z /library/oar/handle/123456789/138311 Title: On the behavior of auxetic inserts : a numerical analysis to derive design guidelines Authors: Di Brizzi, Diego; Graziosi, Serena; Bondin, William; Grima, Joseph N.; Airoldi, Alessandro Abstract: Auxetics are a class of materials and metamaterials with a negative Poisson’s ratio (ν) and have gained tremendous popularity over the last three decades. Many studies have focused on characterizing designs that allow obtaining a negative ν. However, some open issues remain concerning understanding the auxetic behavior in operational conditions. Studies have been centered on analyzing the response of specific auxetic topologies instead of treating auxeticity as a property to be analyzed in a well-defined structural context. This study aims to contribute to the investigation of auxetic materials with a structural application, focusing on maximizing performance. The field of application of auxetics for designing inserts was selected and a model of a nail-cavity system was created to determine the effects of different design choices on the system behavior by exploring relationships between selected parameters and the auxetic insert behavior. The exploration combines finite element modeling analyses with their surrogate models generated by supervised learning algorithms. This approach allows for exploring the system’s behavior in detail, thus demonstrating the potential effectiveness of auxetics when used for such applications. A list of design guidelines is elaborated to support the exploitation of auxetics in nail-cavity systems. Mon, 01 Jan 2024 00:00:00 GMT /library/oar/handle/123456789/138311 2024-01-01T00:00:00Z