Prof. Roger Ellul Micallef

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M.D.(R.U.M.),Ph.D.(Edin.),F.R.C.P.(Edin.),F.R.C.P.(Lond.),Hon.D.Sc.(Westminster), M.O.M.

Professor

Clinical Pharmacology & Therapeutics

Faculty of Medicine & Surgery

Room 207

Chemistry & Pharmacology Building

University of Malta

Msida

+356 2340 2289

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Rector Emeritus

Clinical Pharmacology & Therapeutics

Faculty of Medicine & Surgery

Biography

Roger Ellul-Micallef M.D. (R.U.M.), Ph.D. (Edin.), F.R.C.P. (Edin.) F.R.C.P. (Lond.), Hon. D.Sc. (Westminster), M.O.M. is Professor of Clinical Pharmacology and Therapeutics at the University of Malta. He carried out his postgraduate training in Respiratory Medicine in Sir John Crofton’s department at the University of Edinburgh. He is the author of many peer-reviewed papers published in leading clinical and scientific journals including the British Medical Journal, Lancet, British Journal of Clinical Pharmacology, European Journal of Respiratory Diseases, Thorax, Respiratory Medicine, Postgraduate Medical Journal, International Journal of Immunopharmacology, Clinical Science, and the American Journal of Respiratory Cell and Molecular Biology. Professor Ellul-Micallef has been an invited speaker at many international meetings. He has co-edited two books on bronchial asthma and contributed chapters to a number of postgraduate medical books published in the UK and USA. His research work has led to a better understanding and management of bronchial asthma, establishing the use of glucocorticosteroids as the mainstay in the treatment of this condition. Ellul-Micallef’s contributions were among the first to highlight the importance of using a spacer device when drugs are being administered by inhalation and also emphasized the existence of cough-variant asthma.

Professor Ellul-Micallef was Chairman of the Council of Europe’s Committee on Higher Education and Research (1993-1996), Pro-Rector and later Rector of the University of Malta (1991-2006) and Chairman of the European Access Network (2000-2008). He was awarded the rank of Grande Ufficiale al Merito della Repubblica Italiana, an honorary doctorate by the University of Westminster and the grade of Commandeur de l’Ordre des Palmes Académiques by the French Government for services rendered to Higher Education. He is interested in the History of Medicine, particularly in the development of the Maltese medical tradition and has contributed several papers on this topic both in locally published books and in foreign journals. He is currently president of the Malta Historical Society.

Research Interests

Publications

Ellul-Micallef, R. 2017, Roberto Ranieri Costaguti. The University of Malta's first rector. (in print).

Grech, G.M., Grech, G., Ellul-Micallef, R., Hall, I.P. & Fenech, A.G. 2017, "Investigation into the genetic and functional relevance of the association of rs 12477314 with pulmonary function. (Abst.)", Brit.Pharmacol.Soc., .

Ellul-Micallef, R. 2016, "The Sacra Infermeria -- from its origin to the present day" in Encounters with Valletta. (in print).

Fenech, A.G. & Ellul-Micallef, R. 2016, "Pharmacogenetics of asthma therapeutics", .

Ellul-Micallef, R. 2015, "The plague, theurgy and the plague saints in Malta" in The Quest for Authenticity and Human Dignity Malta, , pp. 177-204.

Grech, G.M., Ellul-Micallef, R., Hall, I. & Fenech, A.G. 2015, "Investigation into the genetic and functional relevance of the association of rs12477314 with pulmonary function.", Malta Medical J., vol. 27, pp. 56.

Ellul-Micallef, R. 2014, "Devils, demons and dementia: the undoing of a Maltese bishop" in Scientia et Religio Malta, , pp. 69-102.

Ellul-Micallef, R. 2013, Zammit of Malta. His times, life and achievements.

Ellul-Micallef, R. 2010, "Cleardo Naudi, the University’s first Professor of Chemistry" in Melita Historica 60th anniversary Malta, , pp. 323-340.

Vella, J., Portelli, M., Ellul-Micallef, R. & Fenech, A.G. 2009, "Pharmacogenetics of the human chemokine receptor 4 (CCR4) gene.", Malta Medical J.Supplement, vol. 21, pp. 173-174.

Ellul-Micallef, R. 2008, "I Cavalieri, l’esperienza maltese" in Milites Templi Perugia, Volumina Editrice, , pp. 87-93.

Ellul-Micallef, R. 2006, "The life and Times of Sir Temi Zammit" in The Sunday Times of Malta 06.08.2006; 13.08.06, pp. 56-57.

Ellul-Micallef, R. 2006, "Tarthuth (Fungus melitensis), for a time, Malta’s quasi singular contribution to Materia Medica." in Celebratio Amicitae Midsea Books Ltd, Malta, , pp. 181-204.

Cordina, M., Vassallo, J., Fenech, A.G., Ellul-Micallef, R. & Cacciottolo, J. 2005, "Asthma medication, lung function and anxiety levels.", Eur Respir J., vol. 26, pp. 445.

Ellul-Micallef, R. 2005, "Auenbrugger and Laennec: two pioneers who have demarcated the development of western thoracic medicine", .

Pace, T., Mifsud, J., Cali-Corleo, R., Fenech, A.G. & Ellul-Micallef, R. 2005, "Medication, recreational drugs and diving", Malta Medical Journal, vol. 17, no. 01, pp. 9.

Cordina, M., Vassallo, J., Fenech, A.G., Ellul-Micallef, R., Azzopardi, J. & Cacciottolo, J.M. 2004, "The degree of adherence to inhaled glucocorticoid therapy in asthma and potential predictors of barriers to adherence.", Pharmacy Education, vol. 4, pp. 27.

Fenech, A.G., Billington, C.K., Swan, C., Richards, S., Hunter, T., Ebejer, M.J., Felice, A.E., Ellul-Micallef, R. & Hall, I.P. 2004, "Novel polymorphisms influencing transcription of the human CHRM2 gene in airway smooth muscle", American journal of respiratory cell and molecular biology, vol. 30, no. 5, pp. 678-686.

Mifsud, J., Gafa, M., Micallef, M., Debono, A. & Ellul-Micallef, R. 2004, "Effect of antiepileptic drugs on in-vitro lymphocyte proliferation assays", EPILEPSIABLACKWELL PUBLISHING INC 350 MAIN ST, MALDEN, MA 02148 USA, , pp. 127.

Ellul-Micallef, R. 2003, "Malta: the years of the Order 1530-1798", Journal of the European Academy of Dermatology \& Venereology, vol. 17, pp. 1.

Fenech, A., Bellington, C., Swan, C., Richards, S., Hunter, T., Ebejer, M.J., Felice, A.E. & Ellul-Micallef, R. 2003, "Transcriptional regulation of the human muscarinic M2 receptor gene.", Malta Med J., vol. 15, pp. 108.

Ellul-Micallef, R. 2002, "Guglielmo Lorenzi: a Malta-based Corsican Corsair with Russian connections." in A Journey through the Centuries. Historical discoveries in Russo-Maltese relations. Malta, , pp. 110-117.

Sghendo, L., Mifsud, J., Ellul-Micallef, R., Portelli, J. & Millership, J.S. 2002, "A sensitive gas chromatographic/mass spectrometric method for the resolution and quantification of ethosuximide enantiomers in biological fluids", Journal of Chromatography B, vol. 772, no. 2, pp. 307-315.

Ellul-Micallef, R. 2001, "The Development of Malta’s Medical �� during the time of the Order of St. John" in Peregrinationes. Acta et Documenta., pp. 17-26.

Fenech, A., Ebejer, M., Felice, A., Ellul-Micallef, R. & Hall, I. 2001, "Mutation screening of the muscarinic M2 and M3 receptor genes in normal and asthmatic subjects", British journal of pharmacology, vol. 133, no. 1, pp. 43-48.

Fenech, A., Wheatley, A., Ebejer, M., Felice, A., Ellul-Micallef, R. & Hall, I. 2001, "Transmission Disequilibrium Testing for a Muscarinic M2 receptor 3’ Untranslated Region Single Nucleotide Polymorphism within asthmatic families.", Amer.J.Respir.Crit.Care.Med., vol. 163, pp. 201.

Micallef, M.J., Darmanin, S., Buhagiar, J.A., Camilleri-Podesta, M., Yamauchi, H., Kurimoto, M., Inglott, A.S. & Ellul-Micallef, R. 2001, "Interferon gamma induction in human melanoma cell/allogeneic leukocyte co-cultures is enhanced by interleukin 18 but drug resistant melanoma cells are poorer inducers of IFN-$\gamma$", International immunopharmacology, vol. 1, no. 2, pp. 295-305.

Ellul-Micallef, R. 1999, "A new venture from an old medical school", Images in paediatric cardiology, vol. 1, no. 1, pp. 1.

Ellul-Micallef, R. 1999, "On the trail of Guglielmo Lorenzi" in Unravelling some family connections in Malta. The Sunday Times of Malta, , pp. 42-43.

Ellul-Micallef, R. 1999, "Sketches of Medical Practice in Sixteenth Century Malta." in Karissime Gotifride Malta University Press, , pp. 102-120.

Fenech, A., Ebejer, M., Felice, A., Ellul-Micallef, R. & Hall, I. 1999, "Mutation screening of the human muscarinic M-2 receptor gene in maltese asthmatic patients", BRITISH JOURNAL OF PHARMACOLOGYSTOCKTON PRESS HOUNDMILLS, BASINGSTOKE RG21 6XS, HAMPSHIRE, ENGLAND, , pp. U66.

Mifsud, J., Buttigieg, A., Debono, A.G. & Ellul-Micallef, R. 1999, "Therapeutic management with the newer antiepileptic drugs in Malta.", Epilepsia, vol. 40, no. 2, pp. 96.

Fenech, A. & Ellul-Micallef, R. 1998, "Selenium, glutathione peroxidase and superoxide dismutase in maltese asthmatic patients: effect of glucocorticoid administration", Pulmonary pharmacology \& therapeutics, vol. 11, no. 4, pp. 301-308.

Ellul-Micallef, R. 1997, "A historical outline of bronchial asthma" in Asthma Lippincott-Raven Press, New York, U.S.A, , pp. 1-37.

Fenech, A. & Ellul-Micallef, R. 1997, "Reactive Oxygen Species and their Defence Mechanisms in Bronchial Asthma", Life, vol. 15, pp. 37-50.

Ellul-Micallef, R. 1996, "The possible effects of climate change on health", Climatic change and the Mediterranean, vol. 2, pp. 406-410.

Ebejer, M.J., Galea Baron, A., Ellul-Micallef, R. & Fenech, F.F. 1995, "Clinical and financial consequences of setting up an asthma clinic at St. Luke’s Hospital", .

Ellul-Micallef, R. 1994, "Antonio Manduca: a sixteenth-century Maltese Huguenot" in Liber Amicorum, Essays on Art, History, Cartography and Bibliography University of Malta, Malta, , pp. 53-67.

Ellul-Micallef, R. 1993, "Current status of hypothalamic - adrenal - pituitary function in bronchial asthma" in Bronchial Asthma Little, Brown and Co, Boston, USA, , pp. 842-854.

Ellul-Micallef, R. 1993, "The effects of inhaled steroids on the hypothalamic-pituitary-adrenal axis", Efficacy and Safety of Inhaled Steroids in Asthma.Amer.Rev.Respir.Dis., vol. 148, pp. 510-513.

Ellul-Micallef, R. 1992, "Glucocorticosteroids", Asthma, Blackwell, Oxford, , pp. 613-658.

Ellul-Micallef, R. 1992, "Implications of Expected Climatic Changes on the Island of Malta Predicted Health Problems Associated with Climate Change", .

Ellul-Micallef, R. 1992, "Bronchial Asthma and Glucocorticoids: Evolving concepts, changing perspectives and re-defined roles" in Collected Papers University of Malta, Malta, , pp. 283-356.

Ellul-Micallef, R. 1992, "Glucocorticoids" in Asthma: Basic mechanisms and clinical management Academic Press Inc, London, , pp. 613-657.

Ellul-Micallef, R. 1991, "The Maltese Medical Tradition: Overseas contacts that have influenced its development" in A case study in International Cross-Currents. University Press, Malta, , pp. 187-198.

Ellul-Micallef, R. 1991, "Robert Koch" in Respiratory Disease in Practice 4, pp. 18-19.

Ellul-Micallef, R. 1991, "Sir John Crofton - A Profile" in Respiratory Disease in Practice 3, pp. 18-19.

Debattista, A., Lenicker, H. & Ellul-Micallef, R. 1990, "Trends in admission rates for asthma at an urban general hospital in Malta.", International Pharmacy Journal, vol. 4, pp. 207-209.

Ellul-Micallef, R. 1989, "Maltese physicians through the ages." in The Cultural Identity of Malta Interprint Ltd, Malta, , pp. 235-262.

Ellul-Micallef, R. 1988, "Glucocorticosteroids-the pharmacological basis of their therapeutic use in bronchial asthma", Asthma: Basic Mechanisms and Clinical Management, eds.PJ Barnes, IW Rodger and NC Thomson (Academic Press, London) p, vol. 653.

Ellul-Micallef, R. 1988, "Scientific research facilities available at the University Library: the research worker's point of view", Libraries and Research in Malta, , pp. 15-19.

Ellul-Micallef, R. 1987, "Mode of action of glucocorticosteroids and their effects on asthmatic airways", Advances in the use of inhaled corticosteroids., , pp. 36-57.

Ellul-Micallef, R. 1987, "'The pharmacokinetics and pharmacodynamics of glucocorticosteroids" in Drug Therapy for Asthma M Dekker Inc, New York, , pp. 463-516.

Ellul-Micallef, R. 1985, "Bronchial hyperresponsiveness and the late", Glucocorticosteroids, Inflammation and Bronchial Hyperreactivity; Symposium at the 3rd Congress of the European Society of Pneumology, Basel, September 19, 1984Elsevier Science \& Technology, , pp. 75.

Ellul-Micallef, R. 1985, "'Current status of hypothalamic-pituitary-adrenal function in bronchial asthma" in Bronchial Asthma, Mechanisms and Therapeutics Little, Brown \& Co Boston, USA, , pp. 680-698.

Ellul-Micallef, R. & Al-Ali, S. 1984, "The spectrum of bronchial asthma in Kuwait", Clinical \& Experimental Allergy, vol. 14, no. 6, pp. 509-517.

Ellul-Micallef, R. 1984, "The Ethics of Clinical Research", Bioethics, , pp. 95-101.

Ellul-Micallef, R. 1983, "Effect of oral sodium cromoglycate and ketotifen in fish-induced bronchial asthma.", Thorax, vol. 38, no. 7, pp. 527-530.

Ellul-Micallef, R. 1983, "Effect of terbutaline sulphate in chronic allergic cough.", Br Med J (Clin Res Ed), vol. 287, no. 6397, pp. 940-943.

Ellul-Micallef, R. & Johansson, S. 1983, "Acute dose-response studies in bronchial asthma with a new corticosteroid, budesonide.", British journal of clinical pharmacology, vol. 15, no. 4, pp. 419-422.

Ellul-Micallef, R. 1983, "Treatment of Bronchial Asthma" in Kuwait Drug Index Almquist \& Wiksell, Uppsala, Sweden, , pp. 451-466.

Ellul-Micallef, R. 1982, "The acute effects of corticosteroids in bronchial asthma.", European journal of respiratory diseases.Supplement, vol. 122, pp. 118-125.

Ellul-Micallef, R. 1982, "Inhibition of fish-induced bronchial asthma by different pharmacological agents.", Am Rev Respir Dis, vol. 125, pp. 62.

Ellul-Micallef, R. 1981, "Asthma in the Desert", Thorax, vol. 36, pp. 712.

Ellul-Micallef, R. 1981, "Disodium cromoglycate and food allergic disease.", J Kor Soc Allerg, vol. 2, pp. 178-180.

Ellul-Micallef, R., Borthwick, R. & McHardy, G. 1980, "The effect of oral prednisolone on gas exchange in chronic bronchial asthma.", British journal of clinical pharmacology, vol. 9, no. 5, pp. 479-482.

Ellul-Micallef, R., Hansson, E. & Johansson, S. 1980, "Budesonide: a new corticosteroid in bronchial asthma.", European journal of respiratory diseases, vol. 61, no. 3, pp. 167-173.

Ellul-Micallef, R., Mohammed, D. & Fenech, F. 1980, "The hypereosinophilic syndrome--a diagnostic enigma.", Postgraduate medical journal, vol. 56, no. 657, pp. 506-508.

Ellul-Micallef, R., Moren, F., Wetterlin, K. & Hidinger, K. 1980, "Use of a special inhaler attachment in asthmatic children.", Thorax, vol. 35, no. 8, pp. 620-623.

Ellul-Micallef, R., Fenech, F. & Parrott, D. 1978, "Comparison of cloprednol and prednisolone in chronic asthmatic patients.", British journal of clinical pharmacology, vol. 6, no. 1, pp. 91-93.

Ellul-Micallef, R., Vassallo, M. & Fenech, F. 1977, "Changes in the epidemiological pattern of disease in the Maltese Islands.", Contributions to Mediterranean Studies, , pp. 221-231.

Fenech, F. & Ellul-Micallef, R. 1977, "FPL 57787; a new orally effective chromone in the treatment of bronchial asthma.", Allergologia et Immunopathologia, vol. 5, pp. 519-521.

Ellul-Micallef, R. 1976, "Asthma: a look at the past", British journal of diseases of the chest, vol. 70, pp. 112-116.

Ellul-Micallef, R., Galdes, A. & Fenech, F. 1976, "Serum zinc levels in corticosteroid-treated asthmatic patients", Postgraduate medical journal, vol. 52, no. 605, pp. 148-150.

Ellul-Micallef, R. 1976, "Altered pulmonary function in bronchial asthma", The St.Lukes Hospital Gazette, , pp. 111-120.

Fenech, F.F., Mallia, C. & Ellul-Micallef, R. 1976, "Pulmonary infarction in healthy young males", .

Ellul-Micallef, R. 1975, "Medical Education in Malta - present trends and future goals", J.Educ.Affairs, vol. 1, pp. 21-28.

Ellul-Micallef, R. & Fenech, F. 1975, "Effect of intravenous prednisolone in asthmatics with diminished adrenergic responsiveness", The Lancet, vol. 306, no. 7948, pp. 1269-1271.

Ellul-Micallef, R. & Fenech, F. 1975, "Intravenous prednisolone in chronic bronchial asthma.", Thorax, vol. 30, no. 3, pp. 312-315.

Ellul-Micallef, R. 1975, "Pulmonary Pharmacokinetics", J.Malta Pharm.Ass., vol. 1, pp. 7-10.

Ellul-Micallef, R. & Fenech, F.F. 1975, "Alveolar cell carcinoma", .

Fenech, F.F., Degiovanni, J., Attard, M. & Ellul-Micallef, R. 1975, "Hiatus hernia at St Lukes Hospital: a three year clinical survey", .

Ellul-Micallef, R., Borthwick, R. & McHardy, G. 1974, "The time-course of response to prednisolone in chronic bronchial asthma", Clinical science, vol. 47, no. 2, pp. 105-117.

Ellul-Micallef, R. & Fenech, F. 1974, Clinical Pharmacological Studies on Corticosteroid Administration to Chronic Asthmatic Patients, Portland Press Limited.

Ellul-Micallef, R., Galdes, A. & Fenech, F.F. 1974, "Determination of serum zinc levels in normal Maltese adults by atomic absorption spectrophotometry", .

Bainbridge, D., Borthwick, R., Ellul-Micallef, R., Fairbrother, M. & McHardy, G. 1973, "Small Airway Disease in Asthma", Thorax, vol. 28, pp. 266.

Borthwick, R., Ellul-Micallef, R. & McHardy, G. 1973, "Corticosteroids in Chronic Bronchial Asthma - The time course of response and the effect on pulmonary gas exchange.", Tubercle, vol. 3, pp. 31.

Ellul-Micallef, R. 1973, "Airway smooth muscle in health and in asthma", British journal of diseases of the chest, vol. 67, no. 2, pp. 107-113.

Ellul-Micallef, R. 1973, "Asthma: a new look at an old disease", .

Ellul-Micallef, R., Borthwick, R. & McHardy, G. 1972, "The Time Course of Response to Corticosteroids in Bronchial Asthma", Clinical science, vol. 43, no. 6, pp. 15.

Ellul-Micallef, R., Borthwick, R. & McHardy, G. 1971, "Time Course of Response to Corticosteroids in Chronic Airway Obstruction", Scot.Med.J., vol. 16, pp. 534.

Ellul-Micallef, R. 1968, "A case of femoral hernia in a young male", .

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