Parenteral glutamine in critical illness : just what the gut needs

Abstract

The role of glutamine as a metabolic fuel for the starving intestines, its capacity to limit bacterial translocation, lung sepsis and a pro-inflammatory cytokine response are reviewed in the context of uncertainities regarding current recommendations for glutamine supplementation in parenterally-fed critically ill patients. Weaknesses in the evidence-base showing benefit of intravenous glutamine supplementation are discussed together with aspects of glutamine supplementation via the enteral route.